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Etrasimod for ulcerative colitis: evaluating phase III results

An Author Correction to this article was published on 03 July 2023

This article has been updated

Recent clinical trials have demonstrated efficacy and safety of etrasimod, a new sphingosine-1-phosphate receptor modulator, in the treatment of patients with moderately-to-severely active ulcerative colitis. Etrasimod is a promising new oral treatment option for ulcerative colitis, although long-term efficacy and safety data should be accumulated.

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Correspondence to Toshifumi Hibi.

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Competing interests

T.H. has received lecture fees from AbbVie, EA Pharma, Janssen, JIMRO, Mitsubishi Tanabe Pharma, Mochida Pharmaceutical, Pfizer, Sandoz, Takeda Pharmaceutical and Zeria, advisory/consultancy fees from AbbVie, Celltrion Healthcare, EA Pharma, Eli Lilly, Gilead Sciences, Janssen, Mitsubishi Tanabe Pharma, Nichi-Iko, Nippon Kayaku, Takeda Pharmaceutical and Zeria, and research grants from AbbVie, Activaid, Alfresa Pharma, Bristol-Myers Squibb, Ferring Pharmaceuticals, Eli Lilly, Gilead Sciences, JIMRO, JMDC Inc., Janssen, Kyorin Pharmaceutical, Miyarisan, Mochida Pharmaceutical, Nippon Kayaku and Pfizer. K.M. received research grants from AbbVie, EA Pharma, Mitsubishi Tanabe Pharma, Mochida Pharmaceutical, Kyorin Pharmaceutical, Kissei Pharmaceutical, JIMRO and Nippon Kayaku, and payment or honoraria for lectures from AbbVie, EA Pharma, Mochida Pharmaceutical, Kyorin Pharmaceutical, Kissei Pharmaceutical, Janssen, JIMRO, Gilead Sciences, Pfizer, Takeda Pharmaceutical, Zeria, Miyarisan, Nippon Kayaku, Celltrion Healthcare, Eli Lilly and Mitsubishi Tanabe Pharma.

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Matsuoka, K., Hibi, T. Etrasimod for ulcerative colitis: evaluating phase III results. Nat Rev Gastroenterol Hepatol 20, 762–763 (2023).

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