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Liver fibrosis with methotrexate — an overestimated risk?

A prospective study suggests that the risk of liver fibrosis with methotrexate treatment has been overestimated. The findings suggest the need to reconsider the intensive strategies and the screening tools that are recommended for monitoring liver fibrosis in patients receiving methotrexate.

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Fig. 1: Proposed relationship between methotrexate treatment and liver fibrosis.


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Correspondence to Raul J. Andrade.

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Andrade, R.J., Björnsson, E.S. Liver fibrosis with methotrexate — an overestimated risk?. Nat Rev Gastroenterol Hepatol 20, 347–348 (2023).

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