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Fibrosis

Autocrine signalling discovery reveals potential therapeutic targets in NASH fibrosis

Nature Reviews Gastroenterology & Hepatology volume 20, page 132 (2023)Cite this article

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Autocrine signalling circuitry and morphological changes in hepatic stellate cells (HSCs) drive advanced fibrosis in nonalcoholic steatohepatitis (NASH), according to new research published in Science Translational Medicine. The work has revealed numerous potential therapeutic targets for the treatment of fibrosis in NASH.

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References

Original article

  • Wang, S. et al. An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis. Sci. Transl Med. 15, eadd3949 (2023)

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  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Ian Fyfe

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  1. Ian Fyfe
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Correspondence to Ian Fyfe.

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Fyfe, I. Autocrine signalling discovery reveals potential therapeutic targets in NASH fibrosis. Nat Rev Gastroenterol Hepatol 20, 132 (2023). https://doi.org/10.1038/s41575-023-00749-4

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  • DOI: https://doi.org/10.1038/s41575-023-00749-4

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