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Gut microbiota in 2022

Nifty new tools for microbiome treatment design

The gut microbiome field is shifting from association to modulation. Microbiota-based treatments come in many shapes and sizes, ranging from dietary intervention to live bacterial products. Recent methodological advances are instrumental to developing innovative new treatment strategies in microbiome-linked pathologies.

Key advances

  • Isotope tracing enabled mapping of nutrient routes in the mouse gut microbiota in vivo3.

  • Engineered Escherichia coli strains enable in vivo recording of transcriptional responses throughout the murine gastrointestinal tract5.

  • CRISPR-edited lactococci encoding β-lactamases control microbiota damage of ampicillin treatment, lowering susceptibility to Clostridioides difficile in mouse models6.

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Fig. 1: Tools for microbiome innovation.


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J.R. thanks the Raes lab, and especially N. Prochazkova, for enticing scientific discussions contributing to this manuscript.

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Correspondence to Jeroen Raes.

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The author declares no competing interests.

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Raes, J. Nifty new tools for microbiome treatment design. Nat Rev Gastroenterol Hepatol 20, 77–78 (2023).

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