The gut microbiome field is shifting from association to modulation. Microbiota-based treatments come in many shapes and sizes, ranging from dietary intervention to live bacterial products. Recent methodological advances are instrumental to developing innovative new treatment strategies in microbiome-linked pathologies.
Isotope tracing enabled mapping of nutrient routes in the mouse gut microbiota in vivo3.
Engineered Escherichia coli strains enable in vivo recording of transcriptional responses throughout the murine gastrointestinal tract5.
CRISPR-edited lactococci encoding β-lactamases control microbiota damage of ampicillin treatment, lowering susceptibility to Clostridioides difficile in mouse models6.
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J.R. thanks the Raes lab, and especially N. Prochazkova, for enticing scientific discussions contributing to this manuscript.
The author declares no competing interests.
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Raes, J. Nifty new tools for microbiome treatment design. Nat Rev Gastroenterol Hepatol 20, 77–78 (2023). https://doi.org/10.1038/s41575-022-00735-2