Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Clinical Outlook
  • Published:

Long-term dynamic ex vivo organ preservation

The feasibility of long-term organ preservation ex vivo has been reported for the first time with proof of concept in human transplantation. Here, we discuss the possible applications of this novel technology in the clinical setting.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Long-term ex vivo organ preservation.


  1. Giwa, S. et al. The promise of organ and tissue preservation to transform medicine. Nat. Biotechnol. 35, 530–542 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Nasralla, D. et al. A randomized trial of normothermic preservation in liver transplantation. Nature 557, 50–56 (2018).

    Article  CAS  PubMed  Google Scholar 

  3. Clavien, P.-A. et al. Transplantation of a human liver following 3 days of ex situ normothermic preservation. Nat. Biotechnol. 40, 1610–1616 (2022).

    Article  CAS  PubMed  Google Scholar 

  4. Eshmuminov, D. et al. An integrated perfusion machine preserves injured human livers for 1 week. Nat. Biotechnol. 38, 189–198 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: liver transplantation. J. Hepatol. 64, 433–485 (2016).

    Article  Google Scholar 

  6. Tian, Y. et al. Liver graft regeneration in a rodent model of auxiliary partial liver xenotransplantation. Transplantation 94, 1136 (2012).

    Article  Google Scholar 

  7. Todo, S. et al. A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation. Hepatology 64, 632–643 (2016).

    Article  CAS  PubMed  Google Scholar 

  8. Taeger, C. D. et al. Extracorporeal perfusion for salvage of major amputates. Ann. Surg. 270, e5–e6 (2019).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Pierre-Alain Clavien.

Ethics declarations

Competing interests

ETH (Swiss Federal Institute of Technology in Zurich) and the University of Zurich (D.E. and P.-A.C.) have applied for a patent on this new perfusion technology (PCT/EP2019/051252).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Eshmuminov, D., Clavien, PA. Long-term dynamic ex vivo organ preservation. Nat Rev Gastroenterol Hepatol 20, 267–268 (2023).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing