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Pancreatitis

Stopped clock promotes fibrosis in chronic pancreatitis

Nature Reviews Gastroenterology & Hepatology volume 19, page 752 (2022)Cite this article

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Dysfunction of the pancreatic clock contributes to fibrosis in chronic pancreatitis, according to new work. The findings suggest that targeting of circadian function has potential as a therapeutic strategy.

The pancreas is one of multiple peripheral organs with an internal circadian clock that influences physiology to synchronize function with external factors and other organ systems. The effects of the pancreatic clock on endocrine function have been well studied. However, little is known about the effects of the pancreatic clock in exocrine function or its influence on disease.

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  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Ian Fyfe

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  1. Ian Fyfe
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Correspondence to Ian Fyfe.

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Fyfe, I. Stopped clock promotes fibrosis in chronic pancreatitis. Nat Rev Gastroenterol Hepatol 19, 752 (2022). https://doi.org/10.1038/s41575-022-00706-7

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