Owing to its simplicity, dextran sulfate sodium (DSS)-induced colitis is one of the most widely used mouse models of colitis. However, the severity of inflammation varies from one experiment to another. In a new study, Forster and colleagues have provided new insights into the DSS model by revealing specific microbial taxa that underlie disease variability.
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The authors warmly thank N. Rolhion who designed the original version of Fig. 1 and helped with preparing the manuscript.
H.S. received consultancy, or lecture fees, from Carenity, Abbvie, Astellas, Danone, Ferring, Mayoly Spindler, MSD, Novartis, Roche, Tillots, Enterome, Maat, BiomX, Biose, Novartis, and Takeda and is also a co-founder of Exeliom Bioscience. N.B. received lecture fees from Tillots and travel grants from Pfizer.
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Benech, N., Sokol, H. Specific gut microbiota taxa as a key source of variability in colitis model. Nat Rev Gastroenterol Hepatol 19, 491–492 (2022). https://doi.org/10.1038/s41575-022-00644-4