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The tumour-associated microbiome

The burgeoning field of intratumoural microbiome research has been driven by advances in next-generation sequencing technologies, with compelling evidence on the role of the microbiota in cancer initiation, progression and patient response to treatment. Here, we discuss new concepts of the tumour-associated microbiota and what is needed to advance the translational impact of these findings in gastrointestinal cancers.

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Fig. 1: The tumour-associated microbiota.


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C.D.J. is supported by the National Institute of Dental and Craniofacial Research of the NIH under award number R01 DE027850 and S.B. is supported by the National Cancer Institute (NCI) under award number R00 CA229984-03.

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Correspondence to Susan Bullman.

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C.D.J. has consulted for Seres Therapeutics and Azitra. S.B. has consulted for GlaxoSmithKline and BioMx; and is on the cancer programme advisory board for BioMx.

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Johnston, C.D., Bullman, S. The tumour-associated microbiome. Nat Rev Gastroenterol Hepatol 19, 347–348 (2022).

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