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NAFLD

Location, location, location — spatial insight into hepatic macrophage populations

The liver microenvironment has a dynamic complexity that has not yet been adequately described. A new omics study sheds light on the hepatic parenchymal and immune cell heterogeneity by focusing on the spatial distribution of myeloid cells and macrophages in homeostasis and nonalcoholic fatty liver disease.

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Fig. 1: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis are intrinsically linked with profound changes in liver histology and the hepatic immune environment.

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Correspondence to Frank Tacke.

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Guillot, A., Tacke, F. Location, location, location — spatial insight into hepatic macrophage populations. Nat Rev Gastroenterol Hepatol 19, 281–282 (2022). https://doi.org/10.1038/s41575-022-00600-2

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