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Natural history of NAFLD: knowns and unknowns

Nature Reviews Gastroenterology & Hepatology volume 19, pages 151–152 (2022)Cite this article

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Although nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, there is a paucity of good-quality data on its natural history and most studies to date have reported on retrospective data. Robust data are required to inform regulatory end points, trial design and models of care.

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Fig. 1: Natural history of nonalcoholic fatty liver disease.

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  1. UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London, UK

    Emmanuel A. Tsochatzis

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  1. Emmanuel A. Tsochatzis
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Correspondence to Emmanuel A. Tsochatzis.

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Competing interests

E.A.T. serves on advisory boards for Engitix, Intercept, Gilead, NovoNordisk, Orphalan and Pfizer, and has received speaker fees from Intercept, Gilead, Oprhalan.

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Tsochatzis, E.A. Natural history of NAFLD: knowns and unknowns. Nat Rev Gastroenterol Hepatol 19, 151–152 (2022). https://doi.org/10.1038/s41575-021-00565-8

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