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Secretory IgA: controlling the gut microbiota

Secretory immunoglobulin A (SIgA) regulates the composition and function of the gut microbiota and modulates its interaction with the host, but how this regulation is achieved is poorly understood. Now, Rollenske and colleagues profile the consequences of SIgA binding to the gut microbiota. They suggest that parallel generic and unique epitope-specific effects of SIgA regulate the intestinal microbiota.

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Fig. 1: Layers of the effects of SIgA on the gut microbiota.


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The authors thank V. Cerovic for discussions and help in editing the manuscript. O.P. is supported by the German Research Foundation (DFG) Project-ID 403224013 – SFB 1382 (B06).

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Correspondence to Oliver Pabst.

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Pabst, O., Izcue, A. Secretory IgA: controlling the gut microbiota. Nat Rev Gastroenterol Hepatol 19, 149–150 (2022).

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