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Single-cell RNA sequencing in pancreatic cancer

Nature Reviews Gastroenterology & Hepatology volume 18, pages 451–452 (2021)Cite this article

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The application of single-cell RNA sequencing platforms has generated notable insights into the heterogeneity underlying pancreatic ductal adenocarcinoma (PDAC), encompassing both the neoplastic compartment and the tumour microenvironment. In this Comment, we discuss the most pertinent findings gleaned from both mouse models and human PDAC samples, as well as future opportunities.

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Acknowledgements

P01CA117969 (A.M. and R.A.D.), P50CA221707 (A.M. and R.A.D.), R01CA218004 (A.M.), R01CA220236 (A.M.), MD Anderson Cancer Moonshot program (A.M. and R.A.D.).

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Authors and Affiliations

  1. Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Jincheng Han & Ronald A. DePinho

  2. Department of Translational Molecular Pathology, The Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Anirban Maitra

Authors
  1. Jincheng Han
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  2. Ronald A. DePinho
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  3. Anirban Maitra
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Correspondence to Anirban Maitra.

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Competing interests

A.M. receives royalties for a pancreatic cancer biomarker test from Cosmos Wisdom Biotechnology, and is listed as an inventor on a patent that has been licensed by Johns Hopkins University to ThriveEarlier Detection. R.A.D. is Founder and Advisor of Tvardi Therapeutics, Asylia Therapeutics, Stellanova Therapeutics, Nirogy Therapeutics and Sporos Bioventures.

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Han, J., DePinho, R.A. & Maitra, A. Single-cell RNA sequencing in pancreatic cancer. Nat Rev Gastroenterol Hepatol 18, 451–452 (2021). https://doi.org/10.1038/s41575-021-00471-z

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