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Novel insights into liver homeostasis and regeneration

Studies of liver regeneration after injury have provided knowledge of the role of external signals and internal metabolic and regenerative pathways. However, less is understood about homeostatic maintenance of normal liver size in the absence of external injury. Three important new studies explore liver regeneration and homeostasis using novel lineage tagging of hepatic cells and single-cell RNA transcriptomics.

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Correspondence to George K. Michalopoulos.

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Michalopoulos, G.K. Novel insights into liver homeostasis and regeneration. Nat Rev Gastroenterol Hepatol 18, 369–370 (2021).

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