Necrotizing enterocolitis (NEC) is an acute intestinal emergency in preterm infants, which is often later complicated by cognitive delay and neurodevelopmental disability. A new study performed in mice suggests that CD4+ T cells can travel from the NEC-inflamed gut to the brain and cause IFNγ-mediated brain injury.
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Coggins, S. A., Wynn, J. L. & Weitkamp, J.-H. Infectious causes of necrotizing enterocolitis. Clin. Perinatol. 42, 133–54 (2015).
Rees, C. M., Pierro, A. & Eaton, S. Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis. Arch. Dis. Child Fetal. Neonatal Ed. 92, F193–198 (2007).
Lodha, A., Asztalos, E. & Moore, A. M. Cytokine levels in neonatal necrotizing enterocolitis and long-term growth and neurodevelopment. Acta Paediatr. 99, 338–343 (2010).
Zhou, Q. et al. Necrotizing enterocolitis induces T lymphocyte–mediated injury in the developing mammalian brain. Sci. Transl. Med. 13, eaay6621 (2021).
Weitkamp, J.-H. et al. Necrotizing enterocolitis is characterized by disrupted immune regulation and diminished mucosal regulatory (FOXP3+) / effector (CD4+, CD8+) T cell ratios. Gut 62, 73–82 (2013).
Nazmi, A. et al. Lymphocytes contribute to the pathophysiology of neonatal brain injury. Front. Neurol. 9, 159 (2018).
Lavoie, P. M. et al. Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis. J. Infect. Dis. 202, 1754–63 (2010).
Duc, D. et al. Disrupting myelin-specific Th17 cell gut homing confers protection in an adoptive transfer experimental autoimmune encephalomyelitis. Cell Reports 2, 378–390 (2019).
Matta, P. et al. In utero exposure to histological chorioamnionitis primes the exo-metabolomic profile of preterm CD4+ T lymphocytes. J. Immunol. 199, 3074–3085 (2017).
Frost, B. L., Modi, B. P., Jaksic, T. & Caplan, M. S. New medical and surgical insights into neonatal necrotizing enterocolitis: a review. JAMA Pediatr. 171, 83–88 (2017).
J.-H.W. serves as a consultant to Roche Diagnostics Corporation.
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Weitkamp, JH. Gut-derived T cells might cause brain injury in NEC. Nat Rev Gastroenterol Hepatol 18, 291–292 (2021). https://doi.org/10.1038/s41575-021-00432-6