Inflammatory bowel disease (IBD) has emerged as a global disease, yet identifying those at higher risk of developing IBD remains challenging. A new study highlights the use of a multi-ethnic polygenic risk score to determine risk of inflammatory bowel disease in a large primary care population.
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References
Hugot, J. P., Chamaillard, M. & Zouali, H. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 411, 599–603 (2001).
Liu, J. Z., van Sommeren, S. & Huang, H. et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat. Genet. 47, 979–986 (2015).
Huang, H., Fang, M. & Jostins, L. et al. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature 547, 173–178 (2017).
Beaudoin, M., Goyette, P. & Boucher, G. et al. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genet. 9, e1003723 (2013).
Rivas, M. A., Graham, D. & Sulem, P. et al. A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis. Nat. Commun. 7, 12342 (2016).
Brant, S. R., Okou, D. T. & Simpson, C. L. et al. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology 152, 206–217 e2 (2017).
Gettler, K. et al. Common and rare variant prediction and penetrance of IBD in a large, multi-ethnic, health system-based biobank cohort. Gastroenterology https://doi.org/10.1053/j.gastro.2020.12.034 (2020).
Tai, Y., Wang, Q. & Korner, H. et al. Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases. Front. Pharmacol. 9, 642 (2018).
Torres, J., Hu, J. & Seki, A. et al. Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice. Gut 69, 42–51 (2020).
Torres, J., Petralia, F. & Sato, T. et al. Serum Biomarkers Identify Patients Who Will Develop Inflammatory Bowel Diseases Up to 5 Years Before Diagnosis. Gastroenterology 159, 96–104 (2020).
Acknowledgements
A.N.A. is supported by grants from the National Institutes of Health, Crohn’s and Colitis foundation, and the Chleck Family Foundation.
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A.N.A. has served on the scientific advisory board of Kyn Therapeutics, Sun Pharma and Gilead.
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Ananthakrishnan, A.N. IBD risk prediction using multi-ethnic polygenic risk scores. Nat Rev Gastroenterol Hepatol 18, 217–218 (2021). https://doi.org/10.1038/s41575-021-00425-5
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DOI: https://doi.org/10.1038/s41575-021-00425-5