A new study elevates our understanding of how the immune system regulates the pathogenesis of biliary atresia through a powerful single-cell approach. Cell-specific transcriptome analyses indicate key roles for macrophages, T cells and B cells in hepatobiliary injury of affected infants.
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The authors declare no competing interests.
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Russi, A.E., Bezerra, J.A. A single-cell view of biliary atresia. Nat Rev Gastroenterol Hepatol 18, 219–220 (2021). https://doi.org/10.1038/s41575-021-00417-5