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BILIARY TRACT

A single-cell view of biliary atresia

A new study elevates our understanding of how the immune system regulates the pathogenesis of biliary atresia through a powerful single-cell approach. Cell-specific transcriptome analyses indicate key roles for macrophages, T cells and B cells in hepatobiliary injury of affected infants.

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References

  1. 1.

    Bezerra, J. A. et al. Biliary atresia: clinical and research challenges for the twenty-first century. Hepatology 68, 1163–1173 (2018).

    Article  Google Scholar 

  2. 2.

    Bezerra, J. A. et al. Genetic induction of proinflammatory immunity in children with biliary atresia. Lancet 360, 1653–1659 (2002).

    Article  Google Scholar 

  3. 3.

    Shivakumar, P. et al. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia. J. Clin. Invest. 114, 322–329 (2004).

    CAS  Article  Google Scholar 

  4. 4.

    Asai, A., Miethke, A. & Bezerra, J. A. Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes. Nat. Rev. Gastroenterol. Hepatol. 12, 342–352 (2015).

    Article  Google Scholar 

  5. 5.

    Bednarek, J. et al. Cytokine-producing B cells promote immune-mediated bile duct injury in murine biliary atresia. Hepatology 68, 1890–1904 (2018).

    CAS  Article  Google Scholar 

  6. 6.

    McHedlidze, T. et al. Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity 39, 357–371 (2013).

    CAS  Article  Google Scholar 

  7. 7.

    Wang, J. et al. Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia. Cell 183, 1867–1883 (2020).

    CAS  Article  Google Scholar 

  8. 8.

    Holt, P. G. & Jones, C. A. The development of the immune system during pregnancy and early life. Allergy 55, 688–697 (2002).

    Article  Google Scholar 

  9. 9.

    Shivakumar, P. et al. Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia. JCI Insight 2, e88747 (2017).

    Article  Google Scholar 

Download references

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Correspondence to Jorge A. Bezerra.

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Russi, A.E., Bezerra, J.A. A single-cell view of biliary atresia. Nat Rev Gastroenterol Hepatol 18, 219–220 (2021). https://doi.org/10.1038/s41575-021-00417-5

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