Chemokines: the (un)usual suspects in pancreatic cancer neural invasion

Pancreatic cancer is notorious for its affinity for invading nerves. A new study using a systematic unbiased RNA-interference screen of neuronal chemokines in cocultures of mouse sensory neurons and pancreatic cancer cells has now identified CCL21 and CXCL10 as key mediators of neural invasion, neural remodelling and pain in pancreatic cancer.

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Fig. 1: Chemokines mediate a vicious cycle between sensory neurons and pancreatic cancer cells.


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Correspondence to Ihsan Ekin Demir.

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Demir, I.E., Mota Reyes, C. Chemokines: the (un)usual suspects in pancreatic cancer neural invasion. Nat Rev Gastroenterol Hepatol (2020).

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