In a new study, cryopreserved human hepatocytes retrieved from livers deemed unsuitable for transplantation were thawed and encapsulated into alginate microbeads and then infused into the peritoneal cavity of a group of children with acute liver failure who were awaiting liver transplantation.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
McKiernan, P. J. Long-term care following paediatric liver transplantation. Arch. Dis. Child Educ. Pract. Ed. 96, 82–86 (2010).
Narkewicz, M. R. et al. A learning collaborative approach increases specificity of diagnosis of acute liver failure in pediatric patients. Clin. Gastroenterol. Hepatol. 16, 1801–1810.e3 (2018).
McKiernan, P. et al. Incidence of primary mitochondrial disease in children younger than 2 years presenting with acute liver failure. J. Pediatr. Gastroenterol. Nutr. 63, 592–597 (2016).
Staufner, C. et al. Defining clinical subgroups and genotype-phenotype correlations in NBAS-associated disease across 110 patients. Genet. Med. https://doi.org/10.1038/s41436-019-0698-4 (2019).
Taylor, S. A. & Whitington, P. F. Neonatal acute liver failure. Liver Transpl. 22, 677–685 (2016).
Feldman, A. G. & Whitington, P. F. Neonatal hemochromatosis. J. Clin. Exp. Hepatol. 3, 313–320 (2013).
Squires, R. H. et al. Intravenous N-acetylcysteine in pediatric patients with non-acetaminophen acute liver failure: a placebo-controlled clinical trial. Hepatology 57, 1542–1549 (2012).
Dhawan, A. et al. Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children. J. Hepatol. https://doi.org/10.1016/j.jhep.2019.12.002 (2019).
Coppin, L., Sokal, E. & Stephenne, X. Hepatocyte transplantation in children. Methods Mol. Biol. 1506, 295–315 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
R.H.S. received a royalty fee for contributions to UpToDate. P.J.M. declares no competing interests.
Rights and permissions
About this article
Cite this article
McKiernan, P.J., Squires, R.H. Bridging transplantation with beads in paediatric acute liver failure. Nat Rev Gastroenterol Hepatol 17, 197–198 (2020). https://doi.org/10.1038/s41575-020-0281-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41575-020-0281-0
