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SARS-CoV-2 in patients with chronic liver disease

An international registry study reports the clinical outcomes of a cohort of patients with chronic liver disease and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. 756 patients with chronic liver disease (386 with cirrhosis and 359 without) from 29 countries were included. In patients with chronic liver disease, risk factors for mortality were advancing age and alcohol-related liver disease. Mortality was 32% in patients with cirrhosis compared with 8% in those without (P < 0.001), and, among patients with cirrhosis, mortality positively correlated with an increase in Child-Turcotte-Pugh (CTP) class. A propensity-score-matched analysis revealed an increased risk of mortality in patients with advanced cirrhosis (CTP-B and CTP-C) compared with a UK cohort of 620 patients with SARS-CoV-2 infection but not chronic liver disease.

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  1. Marjot, T. et al. Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study. J. Hepatol. https://doi.org/10.1016/j.jhep.2020.09.024 (2020)

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Correspondence to Jordan Hindson.

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Hindson, J. SARS-CoV-2 in patients with chronic liver disease. Nat Rev Gastroenterol Hepatol 17, 714 (2020). https://doi.org/10.1038/s41575-020-00384-3

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