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NEUROGASTROENTEROLOGY

The enteric nervous system: the hub in a star network

Nature Reviews Gastroenterology & Hepatology volume 17, pages 717–718 (2020)Cite this article

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The enteric nervous system (ENS) is an important component of gastrointestinal function and a pivotal hub connecting the gut to other organs. A new study now explores the human and mouse ENS at the single-cell level, providing key insights into the transcriptomic landscape of the ENS and its constituent cells.

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References

  1. Lasrado, R. et al. Lineage-dependent spatial and functional organization of the mammalian enteric nervous system. Science 356, 722–726 (2017).

    Article  CAS  Google Scholar 

  2. Zeisel, A. et al. Molecular architecture of the mouse nervous system. Cell 174, 999–1014 (2018).

    Article  CAS  Google Scholar 

  3. Drokhlyansky, E. et al. The human and mouse enteric nervous system at single-cell resolution. Cell 182, 1606–1622 (2020).

    Article  CAS  Google Scholar 

  4. Krishnaswami, S. R. et al. Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons. Nat. Protoc. 11, 499–524 (2016).

    Article  CAS  Google Scholar 

  5. Abdelmoez, M. N. et al. SINC-seq: correlation of transient gene expressions between nucleus and cytoplasm reflects single-cell physiology. Genome Biol. 19, 66 (2018).

    Article  Google Scholar 

  6. Furness, J. B. The enteric nervous system and neurogastroenterology. Nat. Rev. Gastroenterol. Hepatol. 9, 286–294 (2012).

    Article  CAS  Google Scholar 

  7. Obata, Y. et al. Neuronal programming by microbiota regulates intestinal physiology. Nature 578, 284–289 (2020).

    Article  CAS  Google Scholar 

  8. Rao, M. & Gershon, M. D. The bowel and beyond: the enteric nervous system in neurological disorders. Nat. Rev. Gastroenterol. Hepatol. 13, 517–528 (2016).

    Article  CAS  Google Scholar 

  9. De Vadder, F. et al. Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks. Proc. Natl Acad. Sci. USA 115, 6458–6463 (2018).

    Article  CAS  Google Scholar 

  10. Li, Z. et al. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. J. Neurosci. 31, 8998–9009 (2011).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

W.B. is supported by grants from the Research Foundation Flanders (FWO: G036320N) and the Dutch Research Council (NWO VIDI: 016.196.367).

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Authors and Affiliations

  1. Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands

    Ana Carina Bon-Frauches & Werend Boesmans

  2. Biomedical Research Institute (BIOMED), Hasselt University, Hasselt, Belgium

    Werend Boesmans

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  1. Ana Carina Bon-Frauches
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  2. Werend Boesmans
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Correspondence to Werend Boesmans.

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The authors declare no competing interests.

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Bon-Frauches, A.C., Boesmans, W. The enteric nervous system: the hub in a star network. Nat Rev Gastroenterol Hepatol 17, 717–718 (2020). https://doi.org/10.1038/s41575-020-00377-2

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