Fig. 1: Schematic putting results from Lee et al. into context. | Nature Reviews Gastroenterology & Hepatology

Fig. 1: Schematic putting results from Lee et al. into context.

From: Environmental stimuli and gut inflammation via dysbiosis in mouse and man

Fig. 1

The inflammatory effect of antibiotic use and a high-fat diet (HFD) in Lee et al.3 is mediated by impaired mitochondrial bioenergetics in the gut epithelium. This process, in turn, leads to increased oxygenation of the gut lumen, promoting an expansion of pro-inflammatory Enterobacteriaceae. Both 5-amino salicylic acid (5-ASA) and butyrate abrogate the inflammation acting via PPARγ.

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