REGENERATIVE MEDICINE

Modelling hepato-biliary-pancreatic organogenesis

Koike et al. modelled human hepato-biliary-pancreatic (HBP) organogenesis from a culture of pluripotent stem cells. The HBP anlage (primordium) is first specified at the boundary between the foregut and the midgut. A 3D differentiation approach was used to specify gut spheroids with distinct regional identities comprising mesoderm and endoderm. Anteroposterior interactions between these spheroids recapitulated the foregut and midgut boundary in vitro and led to the development of structurally and functionally integrated HBP organoids.

References

Original article

  1. Koike, H. et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary. Nature 574, 112–116 (2019)

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Isobel Leake.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Leake, I. Modelling hepato-biliary-pancreatic organogenesis. Nat Rev Gastroenterol Hepatol 16, 706 (2019). https://doi.org/10.1038/s41575-019-0235-6

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing