NAFLD and risk of cardiovascular disease

Nonalcoholic fatty liver disease (NAFLD) has been thought to be associated with cardiovascular outcomes. A matched cohort study, including >18 million European adults, investigated the risk of acute myocardial infarction (AMI) or stroke in adults with NAFLD or nonalcoholic steatohepatitis (NASH). A diagnosis of NAFLD in routine care does not seem to be associated with risk of AMI or stroke after adjustment for established cardiovascular risk factors. The authors conclude that risk of cardiovascular disease should be assessed in the standard way in these patients, and that NAFLD should not be considered as a risk enhancer.


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  1. Alexander, M. et al. Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults. BMJ 367, I5367 (2019)

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Correspondence to Isobel Leake.

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Leake, I. NAFLD and risk of cardiovascular disease. Nat Rev Gastroenterol Hepatol 16, 706 (2019).

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