LEAP2: A novel regulator of food intake and body weight?

A new study is the first to investigate the relationship between liver-enriched antimicrobial peptide-2 (LEAP2) and different metabolic states, and highlights the reciprocal relationship between LEAP2 and ghrelin (known as the ‘hunger hormone’ for its role in stimulating appetite). These findings could have important implications given the worldwide increase in obesity since 1975.

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Fig. 1: Pharmacological modulation of ghrelin and GHSR.


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The work of the authors is supported by funding of the German Research Foundation (STE 1765/3-2) and Charité University Funding (UFF 89/441-176, A.S.).

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Correspondence to Andreas Stengel.

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The authors declare no competing interests.

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Schalla, M.A., Stengel, A. LEAP2: A novel regulator of food intake and body weight?. Nat Rev Gastroenterol Hepatol 16, 711–712 (2019).

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