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VIRAL HEPATITIS

TCR-grafted T cells restore antiviral immunity

Nature Reviews Gastroenterology & Hepatology volume 16, pages 454–455 (2019)Cite this article

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A new study reports that adoptive transfer of T cells engineered to express HBV-specific T cell receptors (TCRs) — an emerging therapeutic approach to restore antiviral immunity — elicits robust antiviral responses in preclinical models.

Using retroviral transduction, CD4+ and CD8+ T cells — derived from healthy donors and patients with chronic hepatitis B (CHB) — were engineered to stably express high-affinity TCRs specific for HBV envelope or core proteins. In HBV-infected hepatoma cells, co-culture with these TCR-grafted T cells led to undetectable levels of viral antigens and covalently closed circular DNA (cccDNA), suggesting their capacity for virological control.

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Original article

Further reading

  • Maini, M. K. & Bertoletti, A. Global and immunotherapeutic insights into hepatitis B. Nat. Rev. Gastroenterol. Hepatol. 14, 71–72 (2017)

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  1. Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/

    Conor A. Bradley

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  1. Conor A. Bradley
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Correspondence to Conor A. Bradley.

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Bradley, C.A. TCR-grafted T cells restore antiviral immunity. Nat Rev Gastroenterol Hepatol 16, 454–455 (2019). https://doi.org/10.1038/s41575-019-0176-0

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