Cellular diversity in the colon: another brick in the wall

Single-cell RNA profiling of colonic epithelial crypts from healthy volunteers and patients with ulcerative colitis adds pH-regulating colonocytes and goblet cells expressing a major determinant of barrier maintenance to the current arsenal of uncovered colonic epithelial cell types.

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Fig. 1: Overview of colonic crypt structure in health and disease.


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Correspondence to Isabelle Cleynen.

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Cleynen, I., Laukens, D. Cellular diversity in the colon: another brick in the wall. Nat Rev Gastroenterol Hepatol 16, 391–392 (2019).

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