Single-cell RNA profiling of colonic epithelial crypts from healthy volunteers and patients with ulcerative colitis adds pH-regulating colonocytes and goblet cells expressing a major determinant of barrier maintenance to the current arsenal of uncovered colonic epithelial cell types.
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References
Peterson, L. W. & Artis, D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat. Rev. Immunol. 14, 141–153 (2014).
Odenwald, M. A. & Turner, J. R. The intestinal epithelial barrier: a therapeutic target? Nat. Rev. Gastroenterol. Hepatol. 14, 9–21 (2017).
Salim, S. Y. & Soderholm, J. D. Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflamm. Bowel Dis. 17, 362–381 (2011).
Liu, J. Z. et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat. Genet. 47, 979–986 (2015).
Harris, N. The enigmatic tuft cell in immunity. Science 351, 1264–1265 (2016).
Coskun, M. Intestinal epithelium in inflammatory bowel disease. Front. Med. 1, 24 (2014).
Pastorelli, L. et al. Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Front. Immunol. 4, 280 (2013).
Turner, J. R. Intestinal mucosal barrier function in health and disease. Nat. Rev. Immunol. 9, 799–809 (2009).
Vancamelbeke, M. et al. Genetic and transcriptomic bases of intestinal epithelial barrier dysfunction in inflammatory bowel disease. Inflamm. Bowel Dis. 23, 1718–1729 (2017).
Parikh, K. et al. Colonic epithelial cell diversity in health and inflammatory bowel disease. Nature 567, 49–55 (2019).
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Cleynen, I., Laukens, D. Cellular diversity in the colon: another brick in the wall. Nat Rev Gastroenterol Hepatol 16, 391–392 (2019). https://doi.org/10.1038/s41575-019-0161-7
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DOI: https://doi.org/10.1038/s41575-019-0161-7
