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COLORECTAL CANCER

Gut microbial biofilm composition and organisation holds the key to CRC

Nature Reviews Gastroenterology & Hepatology volume 16, pages 329–330 (2019)Cite this article

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A new study provides mechanistic insight into the carcinogenic potential of human colonic mucosal microbial biofilms, confirming that both microbiota composition and organization along with the host inflammatory response are contributing factors to creating the ‘perfect storm’ in terms of colorectal carcinogenesis.

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Fig. 1: Ecological Koch’s postulates fulfilled by the gut microbiota in CRC causation.

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Authors and Affiliations

  1. Microbiome Research Centre, St George and Sutherland Clinical School, University of New South Wales, Sydney, New South Wales, Australia

    Georgina L. Hold

  2. Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada

    Emma Allen-Vercoe

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  1. Georgina L. Hold
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  2. Emma Allen-Vercoe
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Correspondence to Georgina L. Hold.

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The authors declare no competing interests.

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Hold, G.L., Allen-Vercoe, E. Gut microbial biofilm composition and organisation holds the key to CRC. Nat Rev Gastroenterol Hepatol 16, 329–330 (2019). https://doi.org/10.1038/s41575-019-0148-4

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