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Better end points needed in primary sclerosing cholangitis trials

Nature Reviews Gastroenterology & Hepatology (2019) | Download Citation

A new study of a fibroblast growth factor 19 analogue in patients with primary sclerosing cholangitis (PSC) provides provocative results. The data challenge alkaline phosphatase levels as the appropriate surrogate end point in PSC trials and highlight alternatives, urging efforts to identify better clinical end points for this disease.

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  1. Division of Gastroenterology and Center for Autoimmune Liver Diseases, San Gerardo Hospital, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy

    • Alessio Gerussi
    •  & Pietro Invernizzi


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The authors declare no competing interests.

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Correspondence to Pietro Invernizzi.

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