Important studies published in 2018 highlight novel therapeutic strategies along the disease course of IBD, including potential specific dietary modifications at early stages and treatment with adipose-derived stem cells in perianal Crohn’s disease. A treat-to-target approach that involves proactive serial monitoring of inflammatory biomarkers can assist in timely treatment escalation and promises improved patient outcomes.
Specific mixtures of macronutrients and emulsifiers within the diet affect intestinal permeability, gut microbiota density and predispose to intestinal inflammation in IBD2
Allogeneic expanded adipose-derived stem cells result in long-term clinical and radiological healing in patients with treatment-refractory perianal Crohn’s disease3
An approach of tight control, using faecal calprotectin and C-reactive protein measurements to guide treatment escalation, resulted in improved endoscopic and clinical outcomes in patients with Crohn’s disease4
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The authors thank Whitney Tang for assistance with preparing the figure.
S.C.N. has received consulting and speaker fees from AbbVie, Ferring, Janssen, Menarini and Takeda, served as a Scientific Advisory Board member for AbbVie, Ferring and Takeda and received research grants from AbbVie, Ferring and Janssen. A.N.A. has served as a Scientific Advisory Board member for Abbvie and Gilead and received research grants from Pfizer and Merck.
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Ng, S.C., Ananthakrishnan, A.N. New approaches along the IBD course: diet, tight control and stem cells. Nat Rev Gastroenterol Hepatol 16, 82–84 (2019). https://doi.org/10.1038/s41575-018-0088-4