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NAFLD

Gut microbiome, microbial metabolites and the development of NAFLD

Nature Reviews Gastroenterology & Hepatology volume 15, pages 719–720 (2018)Cite this article

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New findings show that a gut microbiome signature derived from metagenomic and phenomic data can accurately predict nonalcoholic fatty liver disease (NAFLD) in obese women. The data highlight a role for phenylacetic acid, a microbial product of aromatic amino acid metabolism, in the cross-talk between the gut microbiome and the host hepatic phenotype.

Refers to Hoyles, L. et al. Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women. Nat. Med. 24, 1070–1080 (2018).

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Fig. 1: The gut microbiome and NAFLD.

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Affiliations

  1. NAFLD Research Center, Department of Medicine, La Jolla, CA, USA

    Cyrielle Caussy & Rohit Loomba

  2. Université Lyon 1, Hospices Civils de Lyon, Lyon, France

    Cyrielle Caussy

  3. Division of Gastroenterology, Department of Medicine, La Jolla, CA, USA

    Rohit Loomba

  4. Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, CA, USA

    Rohit Loomba

Authors
  1. Cyrielle Caussy
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  2. Rohit Loomba
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Correspondence to Rohit Loomba.

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The authors declare no competing interests.

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Caussy, C., Loomba, R. Gut microbiome, microbial metabolites and the development of NAFLD. Nat Rev Gastroenterol Hepatol 15, 719–720 (2018). https://doi.org/10.1038/s41575-018-0058-x

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  • DOI: https://doi.org/10.1038/s41575-018-0058-x

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