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The hepatitis B epidemic and the urgent need for cure preparedness

Nature Reviews Gastroenterology & Hepatology volume 15, pages 517–518 (2018)Cite this article

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More than 250 million people worldwide are chronically infected with the hepatitis B virus (HBV). In this Comment, members of the International Coalition to Eliminate HBV appraise the current policy environment and the need for appropriate cure research and preparedness to complement the WHO global elimination strategy, the HBV vaccine and the well-tolerated but poorly accessed therapy.

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References

  1. Razavi-Shearer, D. et al. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. Lancet Gastroenterol. Hepatol. 3, 383–403 (2018).

    Article  Google Scholar 

  2. World Health Organization. Global health sector strategy on viral hepatitis, 2016–2021. Towards ending viral hepatitis (WHO, 2016).

  3. Papatheodoridis, G. V. et al. Risk of hepatocellular carcinoma in chronic hepatitis B: assessment and modification with current antiviral therapy. J. Hepatol. 62, 956–967 (2015).

    Article  PubMed  Google Scholar 

  4. World Health Organization. Global hepatitis report 2017 (WHO, 2017).

  5. Fattovich, G., Bortolotti, F. & Donato, F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J. Hepatol. 48, 335–352 (2008).

    Article  PubMed  CAS  Google Scholar 

  6. United Nations. Transforming our world: the 2030 agenda for sustainable development. (UN General Assembly, 2015).

  7. Stenberg, K. et al. Financing transformative health systems towards achievement of the health Sustainable Development Goals: a model for projected resource needs in 67 low-income and middle-income countries. Lancet Global Health 5, e875–e887 (2017).

    Article  PubMed  Google Scholar 

  8. Revill, P. et al. Global strategies are required to cure and eliminate HBV infection. Nat. Rev. Gastroenterol. Hepatol. 13, 239–248 (2016).

    Article  PubMed  CAS  Google Scholar 

  9. Nayagam, S. et al. Requirements for global elimination of hepatitis B: a modelling study. Lancet. Infect. Dis. 16, 1399–1408 (2016).

    Article  PubMed  Google Scholar 

  10. Sugarman, J. et al. Ethics and hepatitis B cure research. Gut 66, 389–392 (2017).

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors thank J. Pericàs and H. Nde for their input into an earlier draft of this article.

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Authors and Affiliations

  1. Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain

    Jeffrey V. Lazarus

  2. Baruch S. Blumberg Institute, Doylestown, PA, USA

    Timothy Block

  3. Global Virus Network, Baltimore, MD, USA

    Christian Bréchot

  4. Hepatitis Virus Diversity Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Anna Kramvis

  5. Forum for Collaborative Research, School of Public Health, University of California, Berkeley, CA, USA

    Veronica Miller

  6. World Hepatitis Alliance, London, UK

    Michael Ninburg

  7. International Coalition to Eliminate HBV (ICE-HBV), The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia

    Capucine Pénicaud

  8. German Center for Infection Research (DZIF), Munich partner site, Munich, Germany

    Ulrike Protzer

  9. Center for Disease Analysis Foundation, Lafayette, CO, USA

    Homie Razavi

  10. WHO Collaborating Centre for Viral Hepatitis, Doherty Institute, Melbourne, Australia

    Laura A. Thomas & Benjamin C. Cowie

  11. Burnet Institute, Melbourne, Australia

    Jack Wallace

  12. Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Australia

    Benjamin C. Cowie

Authors
  1. Jeffrey V. Lazarus
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  2. Timothy Block
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  3. Christian Bréchot
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  4. Anna Kramvis
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  5. Veronica Miller
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  6. Michael Ninburg
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  7. Capucine Pénicaud
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  8. Ulrike Protzer
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  9. Homie Razavi
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  10. Laura A. Thomas
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  12. Benjamin C. Cowie
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Corresponding author

Correspondence to Jeffrey V. Lazarus.

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The authors declare no competing interests.

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WHO/UNICEF birth-dose vaccination coverage estimates: http://apps.who.int/immunization_monitoring/globalsummary/timeseries/tswucoveragebcg.html

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Lazarus, J.V., Block, T., Bréchot, C. et al. The hepatitis B epidemic and the urgent need for cure preparedness. Nat Rev Gastroenterol Hepatol 15, 517–518 (2018). https://doi.org/10.1038/s41575-018-0041-6

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