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GUT MICROBIOTA

Broad collateral damage of drugs against the gut microbiome

Nature Reviews Gastroenterology & Hepatologyvolume 15pages457458 (2018) | Download Citation

In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target effects on the growth of human gut bacteria at clinically relevant concentrations. These results emphasize the need for a new field of metagenomic toxicology aimed at a more comprehensive understanding of the toxicity of compounds for humans and their associated microbial communities.

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Acknowledgements

P.J.T. is a Chan Zuckerberg Biohub Investigator and a Nadia’s Gift Foundation Innovator supported by the Damon Runyon Cancer Research Foundation (DRR-42-16), the NIH (R01HL122593) and the Searle Scholars Program (SSP-2016-1352). P.S. is supported by a Canadian Institutes of Health Research fellowship.

Author information

Affiliations

  1. Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA

    • Peter Spanogiannopoulos
    •  & Peter J. Turnbaugh
  2. Chan Zuckerberg Biohub, San Francisco, CA, USA

    • Peter J. Turnbaugh

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Competing interests

P.J.T. is on the scientific advisory board for Kaleido, Seres Therapeutics and WholeBiome. P.S. declares no competing interests.

Corresponding author

Correspondence to Peter J. Turnbaugh.

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DOI

https://doi.org/10.1038/s41575-018-0028-3

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