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GASTRIC CANCER

Gastric cancer: evidence boosts Helicobacter pylori eradication

The efficacy of Helicobacter pylori eradication therapy for the prevention of preneoplastic lesions in gastric cancer remains controversial. A new placebo-controlled trial and a large-scale observational study tackle this problem and show the positive effects of eradication therapy.

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Fig. 1: The point of no return in gastric cancer and Helicobacter pylori eradication.

References

  1. Plummer, M. et al. Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob. Health 4, e609–e616 (2016).

    Article  PubMed  Google Scholar 

  2. Katanoda, K. & Yako-Suketomo, H. Comparison of time trends in stomach cancer incidence (1973–2002) in Asia, from cancer incidence in five continents, Vols IV-IX. Jpn. J. Clin. Oncol. 39, 71–72 (2009).

    Article  PubMed  Google Scholar 

  3. Choi, I. J. et al. Helicobacter pylori therapy for the prevention of metachronous gastric cancer. N. Engl. J. Med. 378, 1085–1095 (2018).

    Article  PubMed  CAS  Google Scholar 

  4. Leung, W. K. et al. Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals. Gastroenterology https://doi.org/10.1053/j.gastro.2018.03.028 (2018).

    Article  PubMed  Google Scholar 

  5. Kato, M. Endoscopic findings of H. pylori infection. In Helicobacter Pylori (eds Suzuki, H., Warren, R. & Marshall, B.) 157–167 (Springer Tokyo, 2016).

  6. Asaka, M., Kato, M. & Graham, D. Y. Strategy for eliminating gastric cancer in Japan. Helicobacter 15, 486–490 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Asaka, M. et al. Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study. Helicobacter 6, 294–299 (2001).

    Article  PubMed  CAS  Google Scholar 

  8. Thung, I. et al. Review article: the global emergence of Helicobacter pylori antibiotic resistance. Aliment. Pharmacol. Ther. 43, 514–533 (2016).

    Article  PubMed  CAS  Google Scholar 

  9. Suzuki, H. & Matsuzaki, J. Helicobacter pylori eradication failure may have confounded the recent large-scale health database study that showed proton pump inhibitors increase gastric cancer risk. Gut. https://doi.org/10.1136/gutjnl-2017-315698 (2017).

    Article  PubMed  Google Scholar 

  10. Matsuzaki, J. et al. Questionnaire-based survey on diagnostic and therapeutic endoscopies and H. pylori eradication for elderly patients in East Asian countries. Digestion 93, 93–102 (2016).

    Article  PubMed  Google Scholar 

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Correspondence to Hidekazu Suzuki.

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Competing interests

H.S. received scholarship funds for the research from Daiichi Sankyo, EA Pharma, Otsuka, Pharmaceutical, and Tsumura, and received service honoraria from Astellas, AstraZeneca, Daiichi Sankyo, Mylan EPD, Otsuka Pharmaceutical, Takeda Pharmaceutical and Tsumura. J.M. declares no competing interests.

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Suzuki, H., Matsuzaki, J. Gastric cancer: evidence boosts Helicobacter pylori eradication. Nat Rev Gastroenterol Hepatol 15, 458–460 (2018). https://doi.org/10.1038/s41575-018-0023-8

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