The efficacy of Helicobacter pylori eradication therapy for the prevention of preneoplastic lesions in gastric cancer remains controversial. A new placebo-controlled trial and a large-scale observational study tackle this problem and show the positive effects of eradication therapy.
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Plummer, M. et al. Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob. Health 4, e609–e616 (2016).
Katanoda, K. & Yako-Suketomo, H. Comparison of time trends in stomach cancer incidence (1973–2002) in Asia, from cancer incidence in five continents, Vols IV-IX. Jpn. J. Clin. Oncol. 39, 71–72 (2009).
Choi, I. J. et al. Helicobacter pylori therapy for the prevention of metachronous gastric cancer. N. Engl. J. Med. 378, 1085–1095 (2018).
Leung, W. K. et al. Effects of Helicobacter pylori treatment on incidence of gastric cancer in older individuals. Gastroenterology https://doi.org/10.1053/j.gastro.2018.03.028 (2018).
Kato, M. Endoscopic findings of H. pylori infection. In Helicobacter Pylori (eds Suzuki, H., Warren, R. & Marshall, B.) 157–167 (Springer Tokyo, 2016).
Asaka, M., Kato, M. & Graham, D. Y. Strategy for eliminating gastric cancer in Japan. Helicobacter 15, 486–490 (2010).
Asaka, M. et al. Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study. Helicobacter 6, 294–299 (2001).
Thung, I. et al. Review article: the global emergence of Helicobacter pylori antibiotic resistance. Aliment. Pharmacol. Ther. 43, 514–533 (2016).
Suzuki, H. & Matsuzaki, J. Helicobacter pylori eradication failure may have confounded the recent large-scale health database study that showed proton pump inhibitors increase gastric cancer risk. Gut. https://doi.org/10.1136/gutjnl-2017-315698 (2017).
Matsuzaki, J. et al. Questionnaire-based survey on diagnostic and therapeutic endoscopies and H. pylori eradication for elderly patients in East Asian countries. Digestion 93, 93–102 (2016).
H.S. received scholarship funds for the research from Daiichi Sankyo, EA Pharma, Otsuka, Pharmaceutical, and Tsumura, and received service honoraria from Astellas, AstraZeneca, Daiichi Sankyo, Mylan EPD, Otsuka Pharmaceutical, Takeda Pharmaceutical and Tsumura. J.M. declares no competing interests.
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Suzuki, H., Matsuzaki, J. Gastric cancer: evidence boosts Helicobacter pylori eradication. Nat Rev Gastroenterol Hepatol 15, 458–460 (2018). https://doi.org/10.1038/s41575-018-0023-8