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MECHANOBIOLOGY

Gut development on a full stomach

Nature Reviews Gastroenterology & Hepatology volume 15, pages 394–395 (2018)Cite this article

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Mechanical forces are important for normal gastrointestinal development and function. Now, He et al. have discovered a population of Drosophila midgut epithelial enteroendocrine cell (EEC) precursors that express the mechanosensitive ion channel Piezo, which generates a calcium influx that drives EEC differentiation and proliferation in response to physiological mechanical stimuli.

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Fig. 1: Mechanical forces trigger enteroendocrine cell differentiation in Drosophila midgut.

References

  1. Deng, H., Gerencser, A. A. & Jasper, H. Signal integration by Ca2+ regulates intestinal stem-cell activity. Nature 528, 212–217 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Gudipaty, S. A. et al. Mechanical stretch triggers rapid epithelial cell division through Piezo1. Nature 543, 118–121 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Eisenhoffer, G. T. et al. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature 484, 546–549 (2012).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Coste, B. et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330, 55–60 (2010).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Pathak, M. M. et al. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc. Natl Acad. Sci. USA 111, 16148–16153 (2014).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. He, L., Si, G., Huang, J., Samuel, A. D. T. & Perrimon, N. Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel. Nature 555, 103–106 (2018).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  7. Bosveld, F. et al. Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis. Nature 530, 495–498 (2016).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Guo, Z. & Ohlstein, B. Stem cell regulation. Bidirectional Notch signaling regulates drosophila intestinal stem cell multipotency. Science 350, aab0988 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Amcheslavsky, A. et al. Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in drosophila. Cell Rep. 9, 32–39 (2014).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Wang, F. et al. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J. Physiol. 595, 79–91 (2017).

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

A.B. appreciates the constructive feedback from members of the Mayo Clinic’s Enteric NeuroScience Program (ENSP), and acknowledges support from NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDKK) grants DK106456 and P30DK084567, and a Research Scholar Award from the American Gastroenterological Association (AGA).

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  1. Enteric Neuroscience Program, Division of Gastroenterology & Hepatology, Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA

    Arthur Beyder

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  1. Arthur Beyder
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Correspondence to Arthur Beyder.

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Beyder, A. Gut development on a full stomach. Nat Rev Gastroenterol Hepatol 15, 394–395 (2018). https://doi.org/10.1038/s41575-018-0012-y

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