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Crohn’s and Parkinson disease: is LRRK2 lurking around the corner?

Exome sequencing of patients with Crohn’s disease (CD) of Ashkenazi Jewish descent and genotyping of large case–control cohorts has identified new CD risk and protective variants of LRRK2, the most common genetic determinant of Parkinson disease. These findings provide new insights into the pathophysiology of these two seemingly unrelated disorders.

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Fig. 1: Variants of LRRK2 associated with risk of Crohn’s disease and Parkinson disease.


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The authors acknowledge the part funding of their research on Parkinson’s disease by Comité d’entente et de coordination des associations de Parkinsoniens (CECAP), France Parkinson et Parkinsoniens de Vendée.

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Correspondence to Pascal Derkinderen.

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The authors declare no competing interests.

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Derkinderen, P., Neunlist, M. Crohn’s and Parkinson disease: is LRRK2 lurking around the corner?. Nat Rev Gastroenterol Hepatol 15, 330–331 (2018).

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