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Adipose tisssue

Controlling brown adipose tissue size through EPAC1

A new study by Reverte-Salisa and colleagues identifies a molecular mechanism through which the cAMP-mediating protein EPAC1 controls the size of brown and beige adipose tissue. This finding opens the door for the development of pharmacological interventions to prevent the decline of brown adipose tissue in obesity and ageing, and thereby improve metabolic health.

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Fig. 1: EPAC1 controls brown and beige adipose tissue size.


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Correspondence to Francesc Villarroya.

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Villarroya, F., Giralt, M. Controlling brown adipose tissue size through EPAC1. Nat Rev Endocrinol 20, 259–260 (2024).

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