Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Adrenal function

Non-invasive daily profiles of tissue adrenal steroids

Nature Reviews Endocrinology volume 19, pages 624–625 (2023)Cite this article

Subjects

In a new study, an ambulatory microdialysis system combined with ultrasensitive liquid chromatography-tandem mass spectrometry enabled the building of a 24-h high-resolution profile of adrenal steroids in the tissue by sampling interstitial fluid in 214 healthy volunteers. Daily and ultradian variations of eight free steroids, including cortisol and aldosterone, have been demonstrated, which opens new diagnostic perspectives for endocrine diseases.

Refers to Upton, T. J. et al. High-resolution daily profiles of tissue adrenal steroids by portable automated collection. Sci. Transl. Med. 15, eadg8464 (2023).

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

References

  1. Fleseriu, M. et al. Consensus on diagnosis and management of Cushing’s disease: a guideline update. Lancet Diabetes Endocrinol. 9, 847–875 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Tabarin, A. et al. Consensus statement by the French Society of Endocrinology (SFE) and French Society of Pediatric Endocrinology & Diabetology (SFEDP) on diagnosis of Cushing’s syndrome. Ann. Endocrinol. (Paris) 83, 119–141 (2022).

    Article  PubMed  Google Scholar 

  3. Bhake, R. C., Leendertz, J. A., Linthorst, A. C. & Lightman, S. L. Automated 24-hours sampling of subcutaneous tissue free cortisol in humans. J. Med. Eng. Technol. 37, 180–184 (2013).

    Article  CAS  PubMed  Google Scholar 

  4. Bhake, R. C. et al. Continuous free cortisol profiles-circadian rhythms in healthy men. J. Clin. Endocrinol. Metab. 104, 5935–5947 (2019).

    Article  CAS  PubMed  Google Scholar 

  5. Bhake, R. et al. Continuous free cortisol profiles in healthy men. J. Clin. Endocrinol. Metab. 105, dgz002 (2020).

    Article  PubMed  Google Scholar 

  6. Upton, T. J. et al. High-resolution daily profiles of tissue adrenal steroids by portable automated collection. Sci. Transl. Med. 15, eadg8464 (2023).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hormonology department, Cochin Hospital, Paris, France

    Fidéline Bonnet-Serrano

  2. INSERM U1016, CNRS UMR8104, Cochin Institute, Paris, France

    Fidéline Bonnet-Serrano & Jérôme Bertherat

  3. Paris Cité University, Paris, France

    Fidéline Bonnet-Serrano & Jérôme Bertherat

  4. Endocrinology department, Center of Reference for Rare Adrenal Diseases, Cochin Hospital, Paris, France

    Jérôme Bertherat

Authors
  1. Fidéline Bonnet-Serrano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jérôme Bertherat
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jérôme Bertherat.

Ethics declarations

Competing interests

J.B. has received grants to his institution from Novartis, HRA Pharma and Recordati, and personal honoraria for consulting, lectures, and/or meeting attendance from Novartis, HRA Pharma, Ipsen, Corcept and Recordati. F.B.-S. has received personal honoraria for symposium attendance from Recordati.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bonnet-Serrano, F., Bertherat, J. Non-invasive daily profiles of tissue adrenal steroids. Nat Rev Endocrinol 19, 624–625 (2023). https://doi.org/10.1038/s41574-023-00901-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41574-023-00901-9

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing