In a new study, an ambulatory microdialysis system combined with ultrasensitive liquid chromatography-tandem mass spectrometry enabled the building of a 24-h high-resolution profile of adrenal steroids in the tissue by sampling interstitial fluid in 214 healthy volunteers. Daily and ultradian variations of eight free steroids, including cortisol and aldosterone, have been demonstrated, which opens new diagnostic perspectives for endocrine diseases.
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J.B. has received grants to his institution from Novartis, HRA Pharma and Recordati, and personal honoraria for consulting, lectures, and/or meeting attendance from Novartis, HRA Pharma, Ipsen, Corcept and Recordati. F.B.-S. has received personal honoraria for symposium attendance from Recordati.
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Bonnet-Serrano, F., Bertherat, J. Non-invasive daily profiles of tissue adrenal steroids. Nat Rev Endocrinol 19, 624–625 (2023). https://doi.org/10.1038/s41574-023-00901-9