Acute inflammation triggers activation of the hypothalamic–pituitary–adrenal axis, but whether it could also impede the adrenocortical response to adrenocorticotropic hormone remains controversial. A new study using preclinical models of acute inflammation demonstrates dysregulation of energy metabolism in adrenocortical cells, resulting in oxidative stress that induces disruption of steroidogenesis.
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The authors declare no competing interests.
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Chortis, V., Breault, D.T. Inflammation-induced adrenal dysfunction. Nat Rev Endocrinol 19, 622–623 (2023). https://doi.org/10.1038/s41574-023-00896-3