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Ageing

Targeting senescent cells in ageing-related endocrine diseases

Nature Reviews Endocrinology volume 19, page 382 (2023)Cite this article

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Originally described in 1961 by Hayflick and Moorhead in the context of serial subculturing of human fibroblasts, cellular senescence is defined as the state of viable irreversible cell-cycle arrest. Over the past few years, preliminary research has indicated that senescent cells could be targeted to treat ageing-related endocrine diseases.

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References

Original article

  • Hickson, L. J. et al. Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine 47, 446–456 (2019)

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Authors and Affiliations

  1. Department of Endocrinology, Hadassah Medical Center, Jerusalem, Israel

    Joshua Stokar

  2. Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    Joshua Stokar

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  1. Joshua Stokar
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Correspondence to Joshua Stokar.

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The author declares no competing interests.

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Stokar, J. Targeting senescent cells in ageing-related endocrine diseases. Nat Rev Endocrinol 19, 382 (2023). https://doi.org/10.1038/s41574-023-00848-x

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  • DOI: https://doi.org/10.1038/s41574-023-00848-x

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