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Adipose tissue

Adipose tissue boosts muscle regeneration by supplying mesenchymal stromal cells

Tissue-resident stem cells have a central role in tissue regeneration, but other accessory cells are also required for efficient regeneration. A new study by Sastourné-Arrey and colleagues reveals a delicate mechanism of skeletal muscle regeneration through an unexpected type of inter-organ communication, in which stromal cells derived from adipose tissue support muscle regeneration.

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  1. Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S. & Tsuchida, K. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat. Cell Biol. 12, 143–152 (2010).

    Article  CAS  PubMed  Google Scholar 

  2. Wosczyna, M. N. et al. Mesenchymal stromal cells are required for regeneration and homeostatic maintenance of skeletal muscle. Cell Rep. 27, 2029–2035.e5 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Oprescu, S. N., Yue, F., Qiu, J., Brito, L. F. & Kuang, S. Temporal dynamics and heterogeneity of cell populations during skeletal muscle regeneration. iScience 23, 100993 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Scott, R. W., Arostegui, M., Schweitzer, R., Rossi, F. M. V. & Underhill, T. M. Hic1 defines quiescent mesenchymal progenitor subpopulations with distinct functions and fates in skeletal muscle regeneration. Cell Stem Cell 25, 797–813.e9 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sastourné-Arrey, Q. et al. Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury. Nat. Commun. 14, 80 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Soliman, H. et al. Multipotent stromal cells: One name, multiple identities. Cell Stem Cell 28, 1690–1707 (2021).

    Article  CAS  PubMed  Google Scholar 

  7. Mogi, M. et al. Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation. J. Cachexia Sarcopenia Muscle 7, 213–224 (2016).

    Article  PubMed  Google Scholar 

  8. Takada, N. et al. Galectin-3 promotes the adipogenic differentiation of PDGFRα+ cells and ectopic fat formation in regenerating muscle. Development 149, dev199443 (2022).

    Article  CAS  PubMed  Google Scholar 

  9. Lendahl, U., Muhl, L. & Betsholtz, C. Identification, discrimination and heterogeneity of fibroblasts. Nat. Commun. 13, 3409 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Bucala, R., Spiegel, L. A., Chesney, J., Hogan, M. & Cerami, A. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol. Med. 1, 71–81 (1994).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Akiyoshi Uezumi.

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Uezumi, A. Adipose tissue boosts muscle regeneration by supplying mesenchymal stromal cells. Nat Rev Endocrinol 19, 317–318 (2023).

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