Tissue-resident stem cells have a central role in tissue regeneration, but other accessory cells are also required for efficient regeneration. A new study by Sastourné-Arrey and colleagues reveals a delicate mechanism of skeletal muscle regeneration through an unexpected type of inter-organ communication, in which stromal cells derived from adipose tissue support muscle regeneration.
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The author declares no competing interests.
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Uezumi, A. Adipose tissue boosts muscle regeneration by supplying mesenchymal stromal cells. Nat Rev Endocrinol 19, 317–318 (2023). https://doi.org/10.1038/s41574-023-00831-6