Findings from the largest longitudinal study (315 participants) on psychosocial functioning in transgender or nonbinary youth after 2 years of gender-affirming hormone (GAH) therapy were recently published in New England Journal of Medicine. At a time of heightened politicization of this treatment, this study adds to the growing literature that demonstrates benefits of GAH therapy for transgender youth.
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References
Chen, D. et al. Psychosocial functioning in transgender youth after 2 years of hormones. N. Engl. J. Med. 388, 240–250 (2023).
Hembree, W. C. et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 102, 3869–3903 (2017).
Coleman, E. et al. Standards of care for the health of transgender and gender diverse people, version 8. Int. J. Transgender Health 23 (Suppl 1), S1–S259 (2022).
American Civil Liberties Union. Mapping attacks on LBGTQ rights in the US state legislature. aclu.org, https://www.aclu.org/legislative-attacks-on-lgbtq-rights (2023).
de Vries, A. L. et al. Young adult psychological outcome after puberty suppression and gender reassignment. Pediatrics 134, 696–704 (2014).
Tordoff, D. M. et al. Mental health outcomes in transgender and nonbinary youths receiving gender-affirming care. JAMA Netw. Open 5, e220978 (2022).
Kuper, L. E., Stewart, S., Preston, S., Lau, M. & Lopez, X. Body dissatisfaction and mental health outcomes of youth on gender-affirming hormone therapy. Pediatrics 145, e20193006 (2020).
Cohen-Kettenis, P. T. & van Goozen, S. H. Pubertal delay as an aid in diagnosis and treatment of a transsexual adolescent. Eur. Child Adolesc. Psychiatry 7, 246–248 (1998).
Arnoldussen, M. et al. Re-evaluation of the Dutch approach: are recently referred transgender youth different compared to earlier referrals? Eur. Child Adolesc. Psychiatry 29, 803–811 (2020).
The Trevor Project. 2022 National survey on LGBTQ youth mental health. thetrevorproject.org, https://www.thetrevorproject.org/survey-2022 (2022).
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Lopez, X., Kuper, L.E. Large study on hormone therapy for transgender youth provides reassurance amid treatment politicization. Nat Rev Endocrinol 19, 319–320 (2023). https://doi.org/10.1038/s41574-023-00824-5
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DOI: https://doi.org/10.1038/s41574-023-00824-5