A new study reveals that exposure of pregnant mice to an endocrine disrupting chemical, bisphenol A, induces multi-transgenerational (up to six) inheritance of obesity in their descendants. This effect depends on CTCF-dependent chromatin reorganization in the sperm, a synergistic outcome of altered DNA methylation, RNA modification and long-range chromatin interactions.
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Research in the Q.C. laboratory is in part supported by NIH (R01HD092431 and R01ES032024).
The authors declare no competing interests.
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Zhang, X., Chen, Q. EDC exposure in 3D genome memory in transgenerational obesity. Nat Rev Endocrinol 19, 192–193 (2023). https://doi.org/10.1038/s41574-023-00810-x