A considerable proportion of autoantibody-negative children with type 1 diabetes mellitus actually have monogenic forms of diabetes mellitus, which enables tailored treatment. Thus, a diagnosis of monogenic diabetes mellitus should be considered and genetically tested for in this group of patients, even if the clinical criteria for monogenic diabetes mellitus are not met.
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The authors acknowledge support from Ministry of Health of the Czech Republic (NV18-01-00078).
The authors declare no competing interests.
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Pruhova, S., Dusatkova, P. Monogenic diabetes mellitus hidden in autoantibody-negative diabetes mellitus. Nat Rev Endocrinol 19, 132–133 (2023). https://doi.org/10.1038/s41574-022-00800-5