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Pancreatic mesenchymal stem cells might protect β-cells

Nature Reviews Endocrinology volume 18, pages 725–726 (2022)Cite this article

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A recent article from Science Translational Medicine demonstrated the importance of pancreas-derived mesenchymal stem cells (PMSCs) for rejuvenating the exocrine pancreas in two mouse models of type 1 diabetes mellitus. PMSCs boosted levels of IL-6 in T helper 1 and T helper 17 cells, which transiently triggered IFNγ and TNF expression and curtailed IL-17 expression to shelter β-cells from immune-mediated damage.

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Fig. 1: PMSCs and protection from type 1 diabetes mellitus — possible mechanisms and open questions.

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Authors and Affiliations

  1. Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

    Rahul Khatri

  2. Clinical Research Unit, Center of Internal Medicine, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany

    Thomas Linn

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  1. Rahul Khatri
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  2. Thomas Linn
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Correspondence to Thomas Linn.

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The authors declare no competing interests.

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Khatri, R., Linn, T. Pancreatic mesenchymal stem cells might protect β-cells. Nat Rev Endocrinol 18, 725–726 (2022). https://doi.org/10.1038/s41574-022-00763-7

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