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GESTATIONAL DIABETES

Diagnosis of gestational diabetes mellitus: the debate continues

A randomized controlled trial demonstrates that using lower glycaemic criteria for diagnosing and treating gestational diabetes mellitus than currently used increases disease prevalence but does not reduce the risk of large-for-gestational-age infants across a population. However, individuals with mild hyperglycaemia who would otherwise remain undiagnosed experienced important health benefits from treatment.

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References

  1. Crowther, C. A. et al. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N. Engl. J. Med. 352, 2477–2486 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Egan, A. M. et al. Epidemiology of gestational diabetes mellitus according to IADPSG/WHO 2013 criteria among obese pregnant women in Europe. Diabetologia 60, 1913–1921 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Gunderson, E. P. et al. Gestational diabetes history and glucose tolerance after pregnancy associated with coronary artery calcium in women during midlife. Circulation 143, 974–987 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Josefson, J. L. et al. Newborn adiposity and cord blood c-peptide as mediators of the maternal metabolic environment and childhood adiposity. Diabetes Care 44, 1194–1202 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Crowther, C. A. et al. Lower versus higher glycemic criteria for diagnosis of gestational diabetes. N. Engl. J. Med. 387, 587–598 (2022).

    Article  PubMed  Google Scholar 

  6. Metzger, B. E. et al. Hyperglycemia and adverse pregnancy outcomes. N. Engl. J. Med. 358, 1991–2002 (2008).

    Article  PubMed  Google Scholar 

  7. Hillier, T. A. et al. A Pragmatic, randomized clinical trial of gestational diabetes screening. N. Engl. J. Med. 384, 895–904 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Davis, E. M. et al. Perinatal outcomes of two screening strategies for gestational diabetes mellitus: a randomized controlled trial. Obstet. Gynecol. 138, 6–15 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Gillespie, P., Cullinan, J., O’Neill, C., Dunne, F. & Atlantic DIP Collaborators. Modeling the independent effects of gestational diabetes mellitus on maternity care and costs. Diabetes Care 36, 1111–1116 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Feig, D. S. et al. Preeclampsia as a risk factor for diabetes: a population-based cohort study. PLoS Med. 10, e1001425 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Fidelma P. Dunne.

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Egan, A.M., Dunne, F.P. Diagnosis of gestational diabetes mellitus: the debate continues. Nat Rev Endocrinol 18, 723–724 (2022). https://doi.org/10.1038/s41574-022-00761-9

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