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ISLET BIOLOGY

Glucagon receptor antagonists might stimulate β-cell expansion

In a recent issue of Cell Reports, Xi et al. reported on their studies of an anti-glucagon receptor antibody in several mouse models of insulin-deficient diabetes mellitus, in which they show substantial increase in β-cell mass from enhanced replication and transdifferentiation of glucagon-expressing α-cells to insulin-expressing β-cells.

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Fig. 1: Glucagon receptor antagonists can lead to regeneration of β-cells in insulin-deficient mice, but their effect in humans is unclear.

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Correspondence to Susan Bonner-Weir.

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Rubin de Celis, M.F., Bonner-Weir, S. Glucagon receptor antagonists might stimulate β-cell expansion. Nat Rev Endocrinol 18, 659–660 (2022). https://doi.org/10.1038/s41574-022-00735-x

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