Adipocyte insulin resistance is a driving force for systemic insulin resistance. Advances in human stem cell culture have established conditions for human adipocytes that give rise to a reproducible population of adipocytes that retain a high level of insulin sensitivity, paving the way for high throughput screening approaches.
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L.G.S. is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) grant #444933586. P.E.S. is supported by US National Institutes of Health (NIH) grants R01-DK55758, R01-DK127274, R01-DK099110, R01-DK131537 and RC2-DK118620.
The authors declare no competing interests.
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Straub, L.G., Scherer, P.E. Insulin sensitive human adipocytes for in vitro studies. Nat Rev Endocrinol 18, 591–592 (2022). https://doi.org/10.1038/s41574-022-00727-x