Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

STEM CELLS

Ketosis improves muscle stem cell resilience

Nature Reviews Endocrinology volume 18, page 458 (2022)Cite this article

Subjects

Fasting can provide benefits for many cell types; however, the effect of fasting on muscle tissue was unknown. A new study in Cell Metabolism has found that ketosis from short-term fasting can induce a protective state in muscle stem cells (MuSCs), resulting in their improved survival.

When cultured in vitro and activated to enter the cell cycle, MuSCs in the deep quiescence state were more likely to survive the activation process, suggesting that they were more resilient to stress than normal MuSCs. Additionally, MuSCs in deep quiescence were more resilient to oxidative stress and acute nutrient deprivation than normal MuSCs and had better long-term survival after transplantation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Endocrinology http://www.nature.com/nrendo/

    Olivia Tysoe

Authors
  1. Olivia Tysoe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Olivia Tysoe.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tysoe, O. Ketosis improves muscle stem cell resilience. Nat Rev Endocrinol 18, 458 (2022). https://doi.org/10.1038/s41574-022-00713-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41574-022-00713-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing